Version 5.4
Mus musculus Protein: Kifc1
Summary
InnateDB Protein IDBP-626682.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kifc1
Protein Name kinesin family member C1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000134572
InnateDB Gene IDBG-251935 (Kifc1)
Protein Structure
UniProt Annotation
Function Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Early endosome {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}.
Disease Associations
Tissue Specificity Highly expressed in E14 embryos, spleen and NIH3T3 cells. Also expressed in testis, brain, lung, kidney and cultured astrocytes. Very low levels in skeletal muscle and heart. {ECO:0000269PubMed:16638812, ECO:0000269PubMed:9115736}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007067 mitotic nuclear division
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005769 early endosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005871 kinesin complex
GO:0005874 microtubule
Protein Structure and Domains
PDB ID MGI:109596
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QWT9
PhosphoSite PhosphoSite-Q9QWT9
TrEMBL
UniProt Splice Variant
Entrez Gene 100502766
UniGene Mm.335713
RefSeq NP_001182227
MGI ID
MGI Symbol Kifc1
OMIM
CCDS CCDS57065
HPRD
IMGT
EMBL AF013117 AF110520 AF221102 AK081484 AM051187 BC003753 BC057162 BC100328 D49544
GenPept AAC39966 AAC97970 AAF34646 AAH03753 AAH57162 AAI00329 BAA19676 BAC38230 CAJ19646

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca