InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcr

Summary

InnateDB Protein

IDBP-626731.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcr

Protein Name

breakpoint cluster region

Synonyms

5133400C09Rik; AI561783; AI853148; mKIAA3017;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126377

InnateDB Gene

IDBG-162464 (Bcr)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007420	brain development
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042472	inner ear morphogenesis
GO:0043314	negative regulation of neutrophil degranulation
GO:0043547	positive regulation of GTPase activity
GO:0046777	protein autophosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0050885	neuromuscular process controlling balance
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88141

InterPro

IPR000008 C2 domain
IPR000198 Rho GTPase-activating protein domain
IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR015123 Bcr-Abl oncoprotein oligomerisation

PFAM

PF00168
PF00620
PF00621
PF00169
PF09036

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00324
SM00325
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt