InnateDB Protein
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IDBP-626774.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Vwc2
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Protein Name
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von Willebrand factor C domain containing 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000128761
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InnateDB Gene
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IDBG-150020 (Vwc2)
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Protein Structure
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Function |
BMP antagonist which may play a role in neural development. Promotes cell adhesion. {ECO:0000269PubMed:17400546, ECO:0000269PubMed:18757743}.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix, basement membrane. Cell junction, synapse {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in the brain (at protein level). It is expressed in the neurons but not the glial cells. {ECO:0000269PubMed:17400546, ECO:0000269PubMed:18757743, ECO:0000269PubMed:22632720}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0010811
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positive regulation of cell-substrate adhesion
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GO:0030514
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negative regulation of BMP signaling pathway
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GO:0045666
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positive regulation of neuron differentiation
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Cellular Component |
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PDB ID |
MGI:2442987
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InterPro |
IPR001007
von Willebrand factor, type C
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PFAM |
PF00093
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PRINTS |
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PIRSF |
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SMART |
SM00214
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C8N3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
319922
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UniGene |
Mm.487612
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RefSeq |
XP_006514796
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MGI ID |
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MGI Symbol |
Vwc2
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OMIM |
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CCDS |
CCDS36111
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HPRD |
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IMGT |
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EMBL |
AB292670
AK044771
AK141514
AL663071
AL663084
BC120564
BC137825
CH466574
DQ421811
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GenPept |
AAI20565
AAI37826
ABD83334
BAC32080
BAE24710
BAF51550
CAI25053
CAI35949
EDL40630
EDL40631
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