InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ap3m2

Summary

InnateDB Protein

IDBP-626784.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap3m2

Protein Name

adaptor-related protein complex 3, mu 2 subunit

Synonyms

5830445E16Rik; AP-3B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128446

InnateDB Gene

IDBG-141332 (Ap3m2)

Protein Structure

UniProt Annotation

Function

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000250, ECO:0000269PubMed:21998198}.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0008089	anterograde axon cargo transport
GO:0016192	vesicle-mediated transport
GO:0048490	anterograde synaptic vesicle transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0030131	clathrin adaptor complex
GO:0030659	cytoplasmic vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1929214

InterPro

IPR001392 Clathrin adaptor, mu subunit
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR011012 Longin-like domain
IPR022775 AP complex, mu/sigma subunit
IPR028565 Mu homology domain

PFAM

PF00928
PF01217

PRINTS

PR00314

PIRSF

PIRSF005992

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt