InnateDB Protein
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IDBP-626914.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cobl
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Protein Name
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cordon-bleu
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000133669
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InnateDB Gene
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IDBG-150918 (Cobl)
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Protein Structure
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Function |
Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells. {ECO:0000269PubMed:17956734, ECO:0000269PubMed:23223303}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Note=Recruited to the cell membrane via interaction with PACSIN1 (By similarity). Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in brain cortex and in the Purkinje cell layer in the cerebellum. Detected in hippocampus neurons, and at lower levels in testis, lung and spleen (at protein level). Detected in embryonic neural tube. {ECO:0000269PubMed:14512015, ECO:0000269PubMed:17956734, ECO:0000269PubMed:23223303, ECO:0000269PubMed:7586755}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:105056
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InterPro |
IPR019025
Cordon-bleu, ubiquitin-like domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF09469
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5NBX1
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PhosphoSite |
PhosphoSite-Q5NBX1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12808
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UniGene |
Mm.395619
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RefSeq |
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MGI ID |
4JHD
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MGI Symbol |
Cobl
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK028833
AK049730
AK122334
AL669822
AL713914
AY308745
BC023264
BC060061
U26967
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GenPept |
AAA92362
AAH23264
AAH60061
AAP74341
BAC26144
BAC33896
BAC65616
CAI35985
CAI35986
CAI36022
CAI36023
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