InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pja2

Summary

InnateDB Protein

IDBP-627057.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pja2

Protein Name

praja 2, RING-H2 motif containing

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134380

InnateDB Gene

IDBG-201879 (Pja2)

Protein Structure

UniProt Annotation

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cell membrane {ECO:0000250}. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses. Co- localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0034236	protein kinase A catalytic subunit binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding

Biological Process

GO:0007616	long-term memory
GO:0010738	regulation of protein kinase A signaling
GO:0016567	protein ubiquitination

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0045211	postsynaptic membrane