Version 5.4
Mus musculus Protein: Mov10
Summary
InnateDB Protein IDBP-627061.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mov10
Protein Name Moloney leukemia virus 10
Synonyms C77703; Mov-10;
Species Mus musculus
Ensembl Protein ENSMUSP00000128246
InnateDB Gene IDBG-183109 (Mov10)
Protein Structure
UniProt Annotation
Function Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, P-body {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0035279 mRNA cleavage involved in gene silencing by miRNA
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
Protein Structure and Domains
PDB ID MGI:97054
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23249
PhosphoSite PhosphoSite-P23249
TrEMBL D3YYR1
UniProt Splice Variant
Entrez Gene 17454
UniGene Mm.406408
RefSeq NP_032645
MGI ID
MGI Symbol Mov10
OMIM
CCDS CCDS38579
HPRD
IMGT
EMBL AC171110 AK004542 BC053743 X52574 X75819
GenPept AAH53743 BAB23358 CAA36803 CAA53453

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca