Version 5.4
Mus musculus Protein: Mocs2
Summary
InnateDB Protein IDBP-627136.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mocs2
Protein Name molybdenum cofactor synthesis 2
Synonyms AI415403;
Species Mus musculus
Ensembl Protein ENSMUSP00000125797
InnateDB Gene IDBG-183838 (Mocs2)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. {ECO:0000255HAMAP-Rule:MF_03052}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000255HAMAP- Rule:MF_03052}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030366 molybdopterin synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0019008 molybdopterin synthase complex
Protein Structure and Domains
PDB ID MGI:1336894
InterPro IPR003448 Molybdopterin biosynthesis MoaE
PFAM PF02391
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z223
PhosphoSite PhosphoSite-Q9Z223
TrEMBL E9PUX1
UniProt Splice Variant
Entrez Gene 17434
UniGene Mm.19027
RefSeq NP_001106845
MGI ID
MGI Symbol Mocs2
OMIM
CCDS CCDS49371
HPRD
IMGT
EMBL AF091872 AK002719 AK010112 AK078782 BC024371 CH466568 CT025598
GenPept AAD14601 AAH24371 BAB22306 BAB26707 BAC37393 EDL18371 EDL18372

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca