InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn2b

Summary

InnateDB Protein

IDBP-627211.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn2b

Protein Name

sodium channel, voltage-gated, type II, beta

Synonyms

2810451E09Rik; AI840361; Gm183;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126826

InnateDB Gene

IDBG-159303 (Scn2b)

Protein Structure

UniProt Annotation

Function

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0007399	nervous system development
GO:0035725	sodium ion transmembrane transport
GO:0046684	response to pyrethroid
GO:0060048	cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity