Version 5.4
| Mus musculus Protein: Unc5d | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-627365.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Unc5d | ||||||||||
| Protein Name | unc-5 homolog D (C. elegans) | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000128521 | ||||||||||
| InnateDB Gene | IDBG-146351 (Unc5d) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Receptor for netrin involved in cell migration. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Expressed in developing limb and mammary gland. {ECO:0000269PubMed:12351186}. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:2389364 | ||||||||||
| InterPro |
IPR000488
Death domain IPR000884 Thrombospondin, type 1 repeat IPR000906 ZU5 IPR003598 Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR011029 Death-like domain IPR013098 Immunoglobulin I-set IPR013151 Immunoglobulin |
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| PFAM |
PF00531
PF00090 PF00791 PF07679 PF00047 |
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART |
SM00005
SM00209 SM00218 SM00408 SM00409 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q8K1S2 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | Q5DTV3 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 210801 | ||||||||||
| UniGene | Mm.416631 | ||||||||||
| RefSeq | NP_694775 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Unc5d | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS40314 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AJ487854 AK220417 BC137615 | ||||||||||
| GenPept | AAI37616 BAD90463 CAD32252 | ||||||||||