Version 5.4
Mus musculus Protein: Tmem176b
Summary
InnateDB Protein IDBP-627415.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem176b
Protein Name transmembrane protein 176B
Synonyms 1810009M01Rik; Clast1; Lr8;
Species Mus musculus
Ensembl Protein ENSMUSP00000128705
InnateDB Gene IDBG-145708 (Tmem176b)
Protein Structure
UniProt Annotation
Function May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells. {ECO:0000250, ECO:0000269PubMed:16814752}.
Subcellular Localization Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed with higher expression in lung, liver, kidney and colon. Expressed in cerebellar granule cells. {ECO:0000269PubMed:16814752}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030154 cell differentiation
GO:2001199 negative regulation of dendritic cell differentiation
Cellular Component
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID MGI:1916348
InterPro IPR007237 CD20-like
PFAM PF04103
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R1Q6
PhosphoSite PhosphoSite-Q9R1Q6
TrEMBL
UniProt Splice Variant
Entrez Gene 65963
UniGene Mm.28385
RefSeq NP_075543
MGI ID
MGI Symbol Tmem176b
OMIM
CCDS CCDS20116
HPRD
IMGT
EMBL AB031386 AF115426 AK007408 AK156042 BC019539 BC022166 CT010176
GenPept AAD28721 AAH19539 AAH22166 BAA83596 BAB25020 BAE33560 CAJ18384

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca