Version 5.4
Mus musculus Protein: Eid1
Summary
InnateDB Protein IDBP-627457.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eid1
Protein Name EP300 interacting inhibitor of differentiation 1
Synonyms 2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22; PTD014;
Species Mus musculus
Ensembl Protein ENSMUSP00000129413
InnateDB Gene IDBG-606643 (Eid1)
Protein Structure
UniProt Annotation
Function Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. {ECO:0000269PubMed:11964378}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11964378}. Cytoplasm {ECO:0000269PubMed:11964378}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269PubMed:11964378}.
Disease Associations
Tissue Specificity Expressed in all adult tissues examined and during embryogenesis. {ECO:0000269PubMed:11964378}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035034 histone acetyltransferase regulator activity
GO:0035035 histone acetyltransferase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0030154 cell differentiation
GO:0035065 regulation of histone acetylation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016235 aggresome
Protein Structure and Domains
PDB ID MGI:1889651
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DCR4
PhosphoSite PhosphoSite-Q9DCR4
TrEMBL
UniProt Splice Variant
Entrez Gene 58521
UniGene Mm.490315
RefSeq NP_079889
MGI ID 4NUF
MGI Symbol Eid1
OMIM
CCDS CCDS50696
HPRD
IMGT
EMBL AF509968 AK002559 AK005258 AK011293 AK014440 AK017543 AK077783 AK078402 AK078409 AK078826 AK148555 AK169604 AK172612 AL929166
GenPept AAM34760 BAB22187 BAB23911 BAB27521 BAB29352 BAB30797 BAC37007 BAC37257 BAC37261 BAC37412 BAE28618 BAE41254 BAE43093 CAM20858

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca