Version 5.4
Mus musculus Protein: Gtf2e2
Summary
InnateDB Protein IDBP-627475.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf2e2
Protein Name general transcription factor II E, polypeptide 2 (beta subunit)
Synonyms 34kDa; AI462509; C330006J08Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000126284
InnateDB Gene IDBG-147962 (Gtf2e2)
Protein Structure
UniProt Annotation
Function Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00682}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005673 transcription factor TFIIE complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1915403
InterPro IPR003166 Transcription factor TFIIE beta subunit, DNA-binding domain
IPR016656 Transcription initiation factor TFIIE, beta subunit
PFAM PF02186
PRINTS
PIRSF PIRSF016398
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D902
PhosphoSite PhosphoSite-Q9D902
TrEMBL
UniProt Splice Variant
Entrez Gene 68153
UniGene Mm.490339
RefSeq NP_001161393
MGI ID
MGI Symbol Gtf2e2
OMIM
CCDS CCDS22236
HPRD
IMGT
EMBL AK007492 AK088342 AK150415 AK153370 AK158783 BC020016
GenPept AAH20016 BAB25066 BAC40294 BAE29539 BAE31938 BAE34662

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca