InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgif1

Summary

InnateDB Protein

IDBP-627552.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgif1

Protein Name

TGFB-induced factor homeobox 1

Synonyms

AA959811; AI462167; Tgif;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127139

InnateDB Gene

IDBG-196427 (Tgif1)

Protein Structure

UniProt Annotation

Function

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down- modulation of the RXR alpha activities (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0070410	co-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007368	determination of left/right symmetry
GO:0008285	negative regulation of cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010470	regulation of gastrulation
GO:0038092	nodal signaling pathway
GO:0042493	response to drug
GO:0045666	positive regulation of neuron differentiation
GO:0048146	positive regulation of fibroblast proliferation
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0060041	retina development in camera-type eye
GO:0071363	cellular response to growth factor stimulus