InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dis3l2

Summary

InnateDB Protein

IDBP-627694.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dis3l2

Protein Name

DIS3 mitotic control homolog (S. cerevisiae)-like 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132673

InnateDB Gene

IDBG-177215 (Dis3l2)

Protein Structure

UniProt Annotation

Function

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255HAMAP-Rule:MF_03045, ECO:0000269PubMed:23594738}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03045, ECO:0000269PubMed:23594738}. Cytoplasm, P-body {ECO:0000255HAMAP-Rule:MF_03045}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003723	RNA binding
GO:0004540	ribonuclease activity
GO:0005515	protein binding

Biological Process

GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0007067	mitotic nuclear division
GO:0008285	negative regulation of cell proliferation
GO:0010587	miRNA catabolic process
GO:0019827	stem cell maintenance
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0051306	mitotic sister chromatid separation
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1990074	polyuridylation-dependent mRNA catabolic process