Version 5.4
Mus musculus Protein: Clnk
Summary
InnateDB Protein IDBP-627702.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clnk
Protein Name cytokine-dependent hematopoietic cell linker
Synonyms MIST;
Species Mus musculus
Ensembl Protein ENSMUSP00000128473
InnateDB Gene IDBG-160384 (Clnk)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT. {ECO:0000269PubMed:10562326, ECO:0000269PubMed:10744659, ECO:0000269PubMed:11463797}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in mast cells of the skin (at protein level). Expressed in cytokine-stimulated hemopoietic cells. {ECO:0000269PubMed:10562326, ECO:0000269PubMed:10744659}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID MGI:1351468
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZE2
PhosphoSite PhosphoSite-Q9QZE2
TrEMBL
UniProt Splice Variant
Entrez Gene 27278
UniGene Mm.440845
RefSeq NP_038776
MGI ID
MGI Symbol Clnk
OMIM
CCDS CCDS51486
HPRD
IMGT
EMBL AB021220 AF187819 AK082826 BC125637 BC125639
GenPept AAF14299 AAI25638 AAI25640 BAA96240 BAC38640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca