Version 5.4
Mus musculus Protein: Rps6ka1
Summary
InnateDB Protein IDBP-628001.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rps6ka1
Protein Name ribosomal protein S6 kinase polypeptide 1
Synonyms Mapkapk-1a; p90-Rsk1; p90rsk; p90Rsk1; p90S6K; Rsk; Rsk-1; Rsk1; S6K-alpha-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000134507
InnateDB Gene IDBG-195412 (Rps6ka1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0006468 protein phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2000491 positive regulation of hepatic stellate cell activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:104558
InterPro IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF06293
PF00433
PRINTS PR00109
PIRSF
SMART SM00133
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9Z278
UniProt Splice Variant
Entrez Gene 20111
UniGene Mm.301827
RefSeq
MGI ID
MGI Symbol Rps6ka1
OMIM
CCDS
HPRD
IMGT
EMBL AF084468 AL837508
GenPept AAD11415

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca