Version 5.4
Mus musculus Protein: Fbll1
Summary
InnateDB Protein IDBP-628104.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbll1
Protein Name fibrillarin-like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000128889
InnateDB Gene IDBG-162727 (Fbll1)
Protein Structure
UniProt Annotation
Function S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus. Note=Fibrillar region of the nucleolus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005730 nucleolus
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:3034689
InterPro IPR000692 Fibrillarin
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01269
PRINTS PR00052
PIRSF PIRSF006540
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80WS3
PhosphoSite PhosphoSite-Q80WS3
TrEMBL
UniProt Splice Variant
Entrez Gene 237730
UniGene Mm.189222
RefSeq NP_001004147
MGI ID
MGI Symbol Fbll1
OMIM
CCDS CCDS36128
HPRD
IMGT
EMBL BC052068
GenPept AAH52068

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca