Version 5.4
Mus musculus Protein: Whamm
Summary
InnateDB Protein IDBP-628128.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Whamm
Protein Name WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000128881
InnateDB Gene IDBG-196363 (Whamm)
Protein Structure
UniProt Annotation
Function Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes (By similarity). Involved as a regulator of Golgi positioning and morphology (By similarity). Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. {ECO:0000250, ECO:0000269PubMed:18614018}.
Subcellular Localization Cytoplasm {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Golgi apparatus, cis- Golgi network {ECO:0000250}. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
Biological Process
GO:0007015 actin filament organization
GO:0008150 biological_process
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID MGI:2142282
InterPro IPR003124 WH2 domain
IPR011026 Wiscott-Aldrich syndrome protein, C-terminal
PFAM PF02205
PRINTS
PIRSF
SMART SM00246
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q571B6
PhosphoSite PhosphoSite-Q571B6
TrEMBL
UniProt Splice Variant
Entrez Gene 434204
UniGene Mm.416675
RefSeq NP_001004185
MGI ID
MGI Symbol Whamm
OMIM
CCDS CCDS52283
HPRD
IMGT
EMBL AK080911 AK220273 BC042749 BC050804
GenPept AAH42749 AAH50804 BAC38074 BAD90198

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca