InnateDB Protein
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IDBP-628343.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hs3st5
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Protein Name
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heparan sulfate (glucosamine) 3-O-sulfotransferase 5
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000129434
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InnateDB Gene
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IDBG-143965 (Hs3st5)
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Protein Structure
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Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008146
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sulfotransferase activity
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GO:0008467
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[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
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Biological Process |
GO:0006477
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protein sulfation
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GO:0015015
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heparan sulfate proteoglycan biosynthetic process, enzymatic modification
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GO:0046596
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regulation of viral entry into host cell
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GO:0050819
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negative regulation of coagulation
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Cellular Component |
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PDB ID |
MGI:2441996
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BSL4
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PhosphoSite |
PhosphoSite-Q8BSL4
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TrEMBL |
B2RXW6
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UniProt Splice Variant |
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Entrez Gene |
319415
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UniGene |
Mm.403120
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RefSeq |
NP_001074677
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MGI ID |
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MGI Symbol |
Hs3st5
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OMIM |
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CCDS |
CCDS35881
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HPRD |
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IMGT |
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EMBL |
AK031910
BC147490
BC147493
BC150973
BC158004
CH466540
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GenPept |
AAI47491
AAI47494
AAI50974
AAI58005
BAC27601
EDL04896
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