InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Txk

Summary

InnateDB Protein

IDBP-628363.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txk

Protein Name

TXK tyrosine kinase

Synonyms

A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129397

InnateDB Gene

IDBG-170081 (Txk)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001012	RNA polymerase II regulatory region DNA binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001865	NK T cell differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032609	interferon-gamma production
GO:0032633	interleukin-4 production
GO:0032729	positive regulation of interferon-gamma production
GO:0046777	protein autophosphorylation
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:102960

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF07714
PF00018
PF14604

PRINTS

PR00401
PR00109
PR00452

PIRSF

SMART

SM00252
SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt