Version 5.4
Homo sapiens Protein: METTL2A
Summary
InnateDB Protein IDBP-62867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METTL2A
Protein Name methyltransferase like 2A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000309610
InnateDB Gene IDBG-62863 (METTL2A)
Protein Structure
UniProt Annotation
Function Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0016427 tRNA (cytosine) methyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0030488 tRNA methylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR004033 UbiE/COQ5 methyltransferase
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR026113 Methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01209
PF08241
PF08242
PRINTS
PIRSF PIRSF037755
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96IZ6
PhosphoSite PhosphoSite-Q96IZ6
TrEMBL B3KM33
UniProt Splice Variant
Entrez Gene 339175
UniGene Hs.381204
RefSeq NP_859076
HUGO HGNC:25755
OMIM 607846
CCDS CCDS45752
HPRD 07795
IMGT
EMBL AC008026 AF161384 AK000991 AK022822 BC006985
GenPept AAF28944 AAH06985 BAB14260 BAG50845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca