InnateDB Protein
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IDBP-62880.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCDC62
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Protein Name
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coiled-coil domain containing 62
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000341471
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InnateDB Gene
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IDBG-62878 (CCDC62)
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Protein Structure
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Function |
Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. {ECO:0000269PubMed:19126643}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:19126643}. Nucleus {ECO:0000269PubMed:19126643}. Note=Mainly nuclear.
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Disease Associations |
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Tissue Specificity |
Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers. {ECO:0000269PubMed:19126643, ECO:0000269PubMed:19165854, ECO:0000269Ref.1, ECO:0000269Ref.4}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0030331
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estrogen receptor binding
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GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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Biological Process |
GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0071392
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cellular response to estradiol stimulus
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Cellular Component |
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PDB ID |
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InterPro |
IPR009053
Prefoldin
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P9F0
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PhosphoSite |
PhosphoSite-Q6P9F0
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TrEMBL |
A0A024RBT8
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UniProt Splice Variant |
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Entrez Gene |
84660
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UniGene |
Hs.736480
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RefSeq |
XP_006719708
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HUGO |
HGNC:30723
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OMIM |
613481
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CCDS |
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HPRD |
15575
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IMGT |
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EMBL |
AK097663
AK124633
AK292466
AY009105
AY254201
BC060796
CH471054
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GenPept |
AAG49396
AAH60796
AAP13075
BAC85909
BAF85155
BAG53505
EAW98344
EAW98345
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