InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLK2

Summary

InnateDB Protein

IDBP-62915.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLK2

Protein Name

tousled-like kinase 2

Synonyms

HsHPK; PKU-ALPHA;

Species

Homo sapiens

Ensembl Protein

ENSP00000340800

InnateDB Gene

IDBG-62909 (TLK2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269PubMed:10523312, ECO:0000269PubMed:11470414, ECO:0000269PubMed:12660173, ECO:0000269PubMed:12955071, ECO:0000269PubMed:20016786, ECO:0000269PubMed:22354037, ECO:0000269PubMed:9427565}.

Subcellular Localization

Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. {ECO:0000269PubMed:9427565, ECO:0000269PubMed:9662073}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001672	regulation of chromatin assembly or disassembly
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007059	chromosome segregation
GO:0010507	negative regulation of autophagy
GO:0016568	chromatin modification
GO:0018105	peptidyl-serine phosphorylation
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0071480	cellular response to gamma radiation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005882	intermediate filament
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt