InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIP1R

Summary

InnateDB Protein

IDBP-62925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIP1R

Protein Name

huntingtin interacting protein 1 related

Synonyms

HIP12; HIP3; ILWEQ;

Species

Homo sapiens

Ensembl Protein

ENSP00000253083

InnateDB Gene

IDBG-62923 (HIP1R)

Protein Structure

UniProt Annotation

Function

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269PubMed:11889126, ECO:0000269PubMed:14732715}.

Subcellular Localization

Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.

Disease Associations

Tissue Specificity

Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006898

receptor-mediated endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005905	coated pit
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle
GO:0030665	clathrin-coated vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001026 Epsin domain, N-terminal
IPR002558 I/LWEQ domain
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal

PFAM

PF01417
PF01608
PF07651

PRINTS

PIRSF

SMART

SM00307
SM00273

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75146