InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUMA1

Summary

InnateDB Protein

IDBP-63045.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUMA1

Protein Name

nuclear mitotic apparatus protein 1

Synonyms

NUMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000351851

InnateDB Gene

IDBG-63041 (NUMA1)

Protein Structure

UniProt Annotation

Function

Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions. {ECO:0000269PubMed:19255246}.

Subcellular Localization

Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Resides in the nuclear matrix during interphases. Dissociates from condensing chromosomes during early prophase, and relocates to the spindle poles via dynein/dynamin association, it remain there until the anaphase onset. Before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident.Isoform Numa-m: Cytoplasm. Note=Mainly clustered at the centrosomal region.Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	76 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000090	mitotic anaphase
GO:0000278	mitotic cell cycle
GO:0006997	nucleus organization
GO:0007067	mitotic nuclear division

Cellular Component

GO:0000139	Golgi membrane
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0016363	nuclear matrix