InnateDB Protein
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IDBP-63062.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MGAT4A
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Protein Name
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mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
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Synonyms
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GnT-4a; GNT-IV; GNT-IVA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264968
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InnateDB Gene
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IDBG-63060 (MGAT4A)
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Protein Structure
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Function |
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
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Subcellular Localization |
Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A soluble form: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. {ECO:0000269PubMed:10024668}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008454
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alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006759
Glycosyl transferase, family 54
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PFAM |
PF04666
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UM21
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PhosphoSite |
PhosphoSite-Q9UM21
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11320
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UniGene |
Hs.594460
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RefSeq |
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HUGO |
HGNC:7047
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OMIM |
604623
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CCDS |
CCDS2036
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HPRD |
06860
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IMGT |
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EMBL |
AB000616
AB053222
AC064860
AC109826
AK304393
BC127107
BC127108
CH471127
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GenPept |
AAI27108
AAI27109
AAY14976
AAY24092
BAA86388
BAC55023
BAG65228
EAX01896
EAX01897
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