Homo sapiens Protein: GFM1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-63158.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GFM1 | ||||||||||||||||||
Protein Name | G elongation factor, mitochondrial 1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000264263 | ||||||||||||||||||
InnateDB Gene | IDBG-63156 (GFM1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. {ECO:0000255HAMAP-Rule:MF_03061, ECO:0000269PubMed:19716793}. | ||||||||||||||||||
Subcellular Localization | Mitochondrion {ECO:0000255HAMAP- Rule:MF_03061}. | ||||||||||||||||||
Disease Associations | Combined oxidative phosphorylation deficiency 1 (COXPD1) [MIM:609060]: A mitochondrial disease resulting in early rapidly progressive hepatoencephalopathy. {ECO:0000269PubMed:15537906, ECO:0000269PubMed:17160893}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000640
Translation elongation factor EFG, V domain IPR000795 Elongation factor, GTP-binding domain IPR004161 Translation elongation factor EFTu/EF1A, domain 2 IPR004540 Translation elongation factor EFG/EF2 IPR005225 Small GTP-binding protein domain IPR005517 Translation elongation factor EFG/EF2, domain IV IPR009000 Translation protein, beta-barrel domain IPR009022 Elongation factor G, III-V domain IPR020568 Ribosomal protein S5 domain 2-type fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00679
PF00009 PF03144 PF03764 PF14492 |
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PRINTS |
PR00315
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PIRSF | |||||||||||||||||||
SMART |
SM00838
SM00889 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q96RP9 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q96RP9 | ||||||||||||||||||
TrEMBL | C9JA25 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 85476 | ||||||||||||||||||
UniGene | Hs.686542 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:13780 | ||||||||||||||||||
OMIM | 606639 | ||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | 07365 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC025033 AC080013 AF309777 AF367998 AK092293 AK315031 BC049210 CH471052 | ||||||||||||||||||
GenPept | AAH49210 AAK53402 AAK58877 BAG37516 BAG52523 EAW78677 EAW78682 | ||||||||||||||||||