Version 5.4
Homo sapiens Protein: LXN
Summary
InnateDB Protein IDBP-63265.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LXN
Protein Name latexin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264265
InnateDB Gene IDBG-63263 (LXN)
Protein Structure
UniProt Annotation
Function Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. {ECO:0000269PubMed:15738388}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain. {ECO:0000269PubMed:11455960}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008191 metalloendopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0006954 inflammatory response
GO:0010951 negative regulation of endopeptidase activity
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009684 Proteinase inhibitor I47, latexin
PFAM PF06907
PRINTS
PIRSF PIRSF011132
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BS40
PhosphoSite PhosphoSite-Q9BS40
TrEMBL
UniProt Splice Variant
Entrez Gene 56925
UniGene Hs.707022
RefSeq NP_064554
HUGO HGNC:13347
OMIM 609305
CCDS CCDS3183
HPRD 14327
IMGT
EMBL AC025033 AC080013 AF087851 AF282594 AF282626 AF303587 BC005346 BC008438
GenPept AAF82807 AAH05346 AAH08438 AAK69518 AAL09331 AAP97162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca