InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF5B

Summary

InnateDB Protein

IDBP-63345.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF5B

Protein Name

eukaryotic translation initiation factor 5B

Synonyms

IF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000289371

InnateDB Gene

IDBG-63343 (EIF5B)

Protein Structure

UniProt Annotation

Function

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR009000 Translation protein, beta-barrel domain
IPR023115 Translation initiation factor IF- 2, domain 3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03144
PF11987

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60841