Version 5.4
Homo sapiens Protein: TACO1
Summary
InnateDB Protein IDBP-63399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TACO1
Protein Name translational activator of mitochondrially encoded cytochrome c oxidase I
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258975
InnateDB Gene IDBG-63397 (TACO1)
Protein Structure
UniProt Annotation
Function Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1. {ECO:0000269PubMed:19503089}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:19503089}.
Disease Associations Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006417 regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR002876 Transcriptional regulator TACO1-like
IPR029072 YebC-like
PFAM PF01709
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BSH4
PhosphoSite PhosphoSite-Q9BSH4
TrEMBL Q8N9Q7
UniProt Splice Variant
Entrez Gene 51204
UniGene
RefSeq NP_057444
HUGO HGNC:24316
OMIM 612958
CCDS CCDS11640
HPRD 17421
IMGT
EMBL AF090929 AK094052 AK315375 AL833861 BC005049 BC007744 CH471109
GenPept AAF24044 AAH05049 AAH07744 BAC04273 BAG37768 CAD38719 EAW94302 EAW94304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca