InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLN1

Summary

InnateDB Protein

IDBP-63420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLN1

Protein Name

talin 1

Synonyms

ILWEQ; TLN;

Species

Homo sapiens

Ensembl Protein

ENSP00000316029

InnateDB Gene

IDBG-63416 (TLN1)

Protein Structure

UniProt Annotation

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	52 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005158	insulin receptor binding
GO:0005178	integrin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0017166	vinculin binding
GO:0030274	LIM domain binding
GO:0032403	protein complex binding
GO:0051015	actin filament binding

Biological Process

GO:0002576	platelet degranulation
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007043	cell-cell junction assembly
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030866	cortical actin cytoskeleton organization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR002404 Insulin receptor substrate-1, PTB
IPR002558 I/LWEQ domain
IPR006077 Vinculin/alpha-catenin
IPR015009 Vinculin-binding site-containing domain
IPR015224 Talin, central
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain

PFAM