InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO3A

Summary

InnateDB Protein

IDBP-63449.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO3A

Protein Name

myosin IIIA

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265944

InnateDB Gene

IDBG-63447 (MYO3A)

Protein Structure

UniProt Annotation

Function

Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. {ECO:0000269PubMed:12032315}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Deafness, autosomal recessive, 30 (DFNB30) [MIM:607101]: A form of non-syndromic deafness characterized by bilateral progressive hearing loss, which first affects the high frequencies. Hearing loss begins in the second decade, and by age 50 is severe in high and middle frequencies and moderate at low frequencies. {ECO:0000269PubMed:12032315}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030898	actin-dependent ATPase activity
GO:0043531	ADP binding
GO:0051015	actin filament binding
GO:0060002	plus-end directed microfilament motor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006468	protein phosphorylation
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0046777	protein autophosphorylation
GO:0048839	inner ear development
GO:0050896	response to stimulus
GO:0051491	positive regulation of filopodium assembly

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0016459	myosin complex
GO:0030175	filopodium
GO:0031941	filamentous actin
GO:0032426	stereocilium bundle tip
GO:0032433	filopodium tip

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001609 Myosin head, motor domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00069
PF07714
PF00063

PRINTS

PR00109
PR00193

PIRSF

SMART

SM00015
SM00242
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt