Version 5.4
Homo sapiens Protein: RILPL2
Summary
InnateDB Protein IDBP-63466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RILPL2
Protein Name Rab interacting lysosomal protein-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000280571
InnateDB Gene IDBG-63464 (RILPL2)
Protein Structure
UniProt Annotation
Function Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:14668488}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at higher level in lung. {ECO:0000269PubMed:14668488}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
Biological Process
GO:0003382 epithelial cell morphogenesis
GO:0006886 intracellular protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
GO:0072372 primary cilium
Protein Structure and Domains
PDB ID
InterPro IPR021563 Rab interacting lysosomal protein
PFAM PF11461
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969X0
PhosphoSite PhosphoSite-Q969X0
TrEMBL
UniProt Splice Variant
Entrez Gene 196383
UniGene Hs.605175
RefSeq NP_659495
HUGO HGNC:28787
OMIM 614093
CCDS CCDS9248
HPRD 10084
IMGT
EMBL AB085763 AK056934 BC013042 CH471054
GenPept AAH13042 BAB71313 BAC76826 EAW98411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca