Version 5.4
Homo sapiens Protein: RILPL1
Summary
InnateDB Protein IDBP-63512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RILPL1
Protein Name Rab interacting lysosomal protein-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366070
InnateDB Gene IDBG-63508 (RILPL1)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:14668488}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at lower level in liver and kidney. {ECO:0000269PubMed:14668488}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0003382 epithelial cell morphogenesis
GO:0006886 intracellular protein transport
GO:1901214 regulation of neuron death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0072372 primary cilium
Protein Structure and Domains
PDB ID
InterPro IPR019143 JNK/Rab-associated protein-1, N-terminal
IPR021563 Rab interacting lysosomal protein
PFAM PF09744
PF11461
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EBL4
PhosphoSite PhosphoSite-Q5EBL4
TrEMBL F5H6W5
UniProt Splice Variant
Entrez Gene 353116
UniGene
RefSeq NP_847884
HUGO HGNC:26814
OMIM 614092
CCDS CCDS45006
HPRD 13435
IMGT
EMBL AC055713 AC145423 AK096697 BC080626 BC089444
GenPept AAH80626 AAH89444 BAC04845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca