InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ID1

Summary

InnateDB Protein

IDBP-63545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ID1

Protein Name

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

Synonyms

bHLHb24; ID;

Species

Homo sapiens

Ensembl Protein

ENSP00000365273

InnateDB Gene

IDBG-63543 (ID1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010621	negative regulation of transcription by transcription factor localization
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043534	blood vessel endothelial cell migration
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048514	blood vessel morphogenesis