InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMED2

Summary

InnateDB Protein

IDBP-63561.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMED2

Protein Name

transmembrane emp24 domain trafficking protein 2

Synonyms

p24; P24A; RNP24;

Species

Homo sapiens

Ensembl Protein

ENSP00000262225

InnateDB Gene

IDBG-63559 (TMED2)

Protein Structure

UniProt Annotation

Function

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. {ECO:0000269PubMed:10761932, ECO:0000269PubMed:17693410, ECO:0000269PubMed:20361938, ECO:0000269PubMed:20427317, ECO:0000269PubMed:21219331}.

Subcellular Localization

Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001893	maternal placenta development
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007030	Golgi organization
GO:0034260	negative regulation of GTPase activity
GO:0035459	cargo loading into vesicle
GO:0048205	COPI coating of Golgi vesicle
GO:0048208	COPII vesicle coating
GO:0048598	embryonic morphogenesis
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030137	COPI-coated vesicle
GO:0030663	COPI-coated vesicle membrane
GO:0032580	Golgi cisterna membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042589	zymogen granule membrane
GO:0043231	intracellular membrane-bounded organelle