InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAD2

Summary

InnateDB Protein

IDBP-63613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAD2

Protein Name

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Synonyms

GAD65;

Species

Homo sapiens

Ensembl Protein

ENSP00000365437

InnateDB Gene

IDBG-63611 (GAD2)

Protein Structure

UniProt Annotation

Function

Catalyzes the production of GABA.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269PubMed:12356867}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:12356867}; Lipid-anchor {ECO:0000269PubMed:12356867}. Golgi apparatus membrane {ECO:0000269PubMed:12356867}; Peripheral membrane protein {ECO:0000269PubMed:12356867}; Cytoplasmic side {ECO:0000269PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004351	glutamate decarboxylase activity
GO:0005515	protein binding
GO:0016595	glutamate binding
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006540	glutamate decarboxylation to succinate
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0019752	carboxylic acid metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042493	response to drug

Cellular Component

GO:0000139	Golgi membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030672	synaptic vesicle membrane
GO:0031225	anchored component of membrane
GO:0031410	cytoplasmic vesicle
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane