Version 5.4
Homo sapiens Protein: GTF2H3
Summary
InnateDB Protein IDBP-63640.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF2H3
Protein Name general transcription factor IIH, polypeptide 3, 34kDa
Synonyms BTF2; P34; TFB4; TFIIH;
Species Homo sapiens
Ensembl Protein ENSP00000228955
InnateDB Gene IDBG-63638 (GTF2H3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004672 protein kinase activity
GO:0008094 DNA-dependent ATPase activity
GO:0008135 translation factor activity, nucleic acid binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006412 translation
GO:0006468 protein phosphorylation
GO:0010467 gene expression
GO:0016032 viral process
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0000439 core TFIIH complex
GO:0005654 nucleoplasm
GO:0005675 holo TFIIH complex
Protein Structure and Domains
PDB ID
InterPro IPR004600 TFIIH subunit Tfb4/p34
PFAM PF03850
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13889
PhosphoSite PhosphoSite-Q13889
TrEMBL
UniProt Splice Variant
Entrez Gene 2967
UniGene Hs.599503
RefSeq NP_001258796
HUGO HGNC:4657
OMIM 601750
CCDS CCDS61275
HPRD 07531
IMGT
EMBL AC117503 AF548661 AK298128 AK313200 BC039726 BC047868 BC065250 CH471054 Z30093
GenPept AAH39726 AAH47868 AAH65250 AAN40702 BAG36016 BAG60408 CAA82909 EAW98426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca