Version 5.4
Homo sapiens Protein: SPTSSB
Summary
InnateDB Protein IDBP-63718.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPTSSB
Protein Name serine palmitoyltransferase, small subunit B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352097
InnateDB Gene IDBG-63716 (SPTSSB)
Protein Structure
UniProt Annotation
Function Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction. {ECO:0000269PubMed:19416851}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expression is seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells. {ECO:0000269PubMed:15777716}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004758 serine C-palmitoyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0030148 sphingolipid biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
GO:0017059 serine C-palmitoyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR024512 Small subunit of serine palmitoyltransferase-like
PFAM PF11779
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFR3
PhosphoSite PhosphoSite-Q8NFR3
TrEMBL
UniProt Splice Variant
Entrez Gene 165679
UniGene Hs.369104
RefSeq NP_001035189
HUGO HGNC:24045
OMIM 610412
CCDS CCDS33887
HPRD 16476
IMGT
EMBL AF458592 AK312144 BC065208 BC071875 BC107756 CH471052
GenPept AAH65208 AAH71875 AAI07757 AAM49720 BAG35080 EAW78616 EAW78617

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca