Version 5.4
Homo sapiens Protein: APBB1IP
Summary
InnateDB Protein IDBP-63724.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APBB1IP
Protein Name amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365411
InnateDB Gene IDBG-63722 (APBB1IP)
Protein Structure
UniProt Annotation
Function Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion. {ECO:0000269PubMed:14530287, ECO:0000269PubMed:15469846}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F- actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. {ECO:0000269PubMed:14530287, ECO:0000269PubMed:15469846}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0030168 platelet activation
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR000159 Ras-association
IPR001849 Pleckstrin homology domain
IPR029071 Ubiquitin-related domain
PFAM PF00788
PF00169
PRINTS
PIRSF
SMART SM00314
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z5R6
PhosphoSite PhosphoSite-Q7Z5R6
TrEMBL
UniProt Splice Variant
Entrez Gene 54518
UniGene
RefSeq NP_061916
HUGO HGNC:17379
OMIM 609036
CCDS CCDS31167
HPRD 16420
IMGT
EMBL AB085852 AL160287 AY152730 BC054516
GenPept AAH54516 AAN75525 BAC41256 CAH70339

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca