InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF17

Summary

InnateDB Protein

IDBP-63759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF17

Protein Name

Rho guanine nucleotide exchange factor (GEF) 17

Synonyms

p164-RhoGEF; P164RHOGEF; TEM4;

Species

Homo sapiens

Ensembl Protein

ENSP00000263674

InnateDB Gene

IDBG-63757 (ARHGEF17)

Protein Structure

UniProt Annotation

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269PubMed:12071859}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in the heart. {ECO:0000269PubMed:12071859}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0007155	cell adhesion
GO:0007264	small GTPase mediated signal transduction
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway