Version 5.4
Homo sapiens Protein: RNF149
Summary
InnateDB Protein IDBP-63768.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF149
Protein Name ring finger protein 149
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295317
InnateDB Gene IDBG-63766 (RNF149)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. {ECO:0000269PubMed:22628551}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031647 regulation of protein stability
GO:0035690 cellular response to drug
GO:0043409 negative regulation of MAPK cascade
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR003137 Protease-associated domain, PA
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF02225
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NC42
PhosphoSite PhosphoSite-Q8NC42
TrEMBL Q53SV6
UniProt Splice Variant
Entrez Gene 284996
UniGene Hs.142074
RefSeq NP_775918
HUGO HGNC:23137
OMIM
CCDS CCDS2051
HPRD 11513
IMGT
EMBL AC013722 AC073643 AK074985 AK075141 AM392566 AY450390 BC019355 BC032328 BC045743
GenPept AAH19355 AAH32328 AAH45743 AAR21083 AAY14775 AAY15089 BAC11334 BAC11430 CAL37444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca