Version 5.4
Homo sapiens Protein: RELT
Summary
InnateDB Protein IDBP-63783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RELT
Protein Name RELT tumor necrosis factor receptor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000064780
InnateDB Gene IDBG-63781 (RELT)
Protein Structure
UniProt Annotation
Function Mediates activation of NF-kappa-B. May play a role in T- cell activation.
Subcellular Localization Cell membrane {ECO:0000269PubMed:16389068}; Single-pass type I membrane protein {ECO:0000269PubMed:16389068}. Cytoplasm {ECO:0000269PubMed:16389068}.
Disease Associations
Tissue Specificity Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas. {ECO:0000269PubMed:16389068}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR022248 TNF receptor family, RELT
IPR022333 Tumour necrosis factor receptor 19-like
PFAM PF12606
PRINTS PR01970
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969Z4
PhosphoSite PhosphoSite-Q969Z4
TrEMBL F5H2T5
UniProt Splice Variant
Entrez Gene 84957
UniGene Hs.533720
RefSeq NP_689408
HUGO HGNC:13764
OMIM 611211
CCDS CCDS8222
HPRD 15544
IMGT
EMBL AF319553 AK027899 AK074128 AP000562 AP000763 BC001812 BC017279 BC051810 CH471076
GenPept AAH17279 AAH51810 AAK77356 BAB55441 BAB84954 EAW74893 EAW74894 EAW74896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca