InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP4K4

Summary

InnateDB Protein

IDBP-63859.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K4

Protein Name

mitogen-activated protein kinase kinase kinase kinase 4

Synonyms

FLH21957; HEL-S-31; HGK; MEKKK4; NIK;

Species

Homo sapiens

Ensembl Protein

ENSP00000314363

InnateDB Gene

IDBG-63853 (MAP4K4)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. {ECO:0000269PubMed:21690388, ECO:0000269PubMed:9890973}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14966141}.

Disease Associations

Tissue Specificity

Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. {ECO:0000269PubMed:9890973}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0046328	regulation of JNK cascade
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt