InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCARB1

Summary

InnateDB Protein

IDBP-63954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCARB1

Protein Name

scavenger receptor class B, member 1

Synonyms

CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261693

InnateDB Gene

IDBG-63952 (SCARB1)

Protein Structure

UniProt Annotation

Function

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001786	phosphatidylserine binding
GO:0001875	lipopolysaccharide receptor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0008035	high-density lipoprotein particle binding
GO:0030169	low-density lipoprotein particle binding
GO:0034185	apolipoprotein binding
GO:0034186	apolipoprotein A-I binding
GO:0042803	protein homodimerization activity
GO:0070506	high-density lipoprotein particle receptor activity

Biological Process

GO:0001935	endothelial cell proliferation
GO:0006702	androgen biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0006910	phagocytosis, recognition
GO:0007155	cell adhesion
GO:0010595	positive regulation of endothelial cell migration
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010886	positive regulation of cholesterol storage
GO:0010899	regulation of phosphatidylcholine catabolic process
GO:0015914	phospholipid transport
GO:0015920	lipopolysaccharide transport
GO:0016032	viral process
GO:0030301	cholesterol transport
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032497	detection of lipopolysaccharide
GO:0033344	cholesterol efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0034383	low-density lipoprotein particle clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0042060	wound healing
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043534	blood vessel endothelial cell migration
GO:0043654	recognition of apoptotic cell
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0044406	adhesion of symbiont to host
GO:0045087	innate immune response (InnateDB)
GO:0050764	regulation of phagocytosis
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0070328	triglyceride homeostasis
GO:0070508	cholesterol import

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030666	endocytic vesicle membrane
GO:0031528	microvillus membrane
GO:0070062	extracellular vesicular exosome