InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCARB1

Summary

InnateDB Protein

IDBP-63958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCARB1

Protein Name

scavenger receptor class B, member 1

Synonyms

CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000343795

InnateDB Gene

IDBG-63952 (SCARB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001786	phosphatidylserine binding
GO:0001875	lipopolysaccharide receptor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0030169	low-density lipoprotein particle binding
GO:0034185	apolipoprotein binding
GO:0034186	apolipoprotein A-I binding
GO:0070506	high-density lipoprotein particle receptor activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0010595	positive regulation of endothelial cell migration
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010886	positive regulation of cholesterol storage
GO:0010899	regulation of phosphatidylcholine catabolic process
GO:0015914	phospholipid transport
GO:0015920	lipopolysaccharide transport
GO:0016032	viral process
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032497	detection of lipopolysaccharide
GO:0033344	cholesterol efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0034383	low-density lipoprotein particle clearance
GO:0034384	high-density lipoprotein particle clearance
GO:0042060	wound healing
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043654	recognition of apoptotic cell
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0044406	adhesion of symbiont to host
GO:0045087	innate immune response (InnateDB)
GO:0050764	regulation of phagocytosis
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0070328	triglyceride homeostasis
GO:0070508	cholesterol import

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0030666	endocytic vesicle membrane
GO:0070062	extracellular vesicular exosome