Version 5.4
Homo sapiens Protein: PAAF1
Summary
InnateDB Protein IDBP-64025.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAAF1
Protein Name proteasomal ATPase-associated factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365564
InnateDB Gene IDBG-64021 (PAAF1)
Protein Structure
UniProt Annotation
Function Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. {ECO:0000269PubMed:15831487, ECO:0000269PubMed:17289585, ECO:0000269PubMed:22316138}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in kidney, brain and testis. {ECO:0000269PubMed:15831487}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated
Total 43 [view]
Protein-Protein 42 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016032 viral process
Cellular Component
GO:0000502 proteasome complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRP4
PhosphoSite PhosphoSite-Q9BRP4
TrEMBL F5H3I1
UniProt Splice Variant
Entrez Gene 80227
UniGene Hs.635189
RefSeq XP_005274366
HUGO HGNC:25687
OMIM
CCDS CCDS58157
HPRD 07761
IMGT
EMBL AF087895 AK021910 AK222501 AK298258 AK316394 AP002770 BC006142 BC021541 BC028628 CH471076
GenPept AAH06142 AAH21541 AAH28628 AAP97194 BAB13933 BAD96221 BAG60522 BAH14765 EAW74917 EAW74919

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca