InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEK

Summary

InnateDB Protein

IDBP-64040.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEK

Protein Name

DEK oncogene

Synonyms

D6S231E;

Species

Homo sapiens

Ensembl Protein

ENSP00000244776

InnateDB Gene

IDBG-64038 (DEK)

Protein Structure

UniProt Annotation

Function

Involved in chromatin organization. {ECO:0000269PubMed:17524367}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17524367, ECO:0000269PubMed:19695025}. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Disease Associations

Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non- lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.

Tissue Specificity

Ubiquitous. Expressed at relatively high levels.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0042393	histone binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0016568	chromatin modification
GO:0019079	viral genome replication
GO:2000779	regulation of double-strand break repair