Version 5.4
Homo sapiens Protein: RNF144B
Summary
InnateDB Protein IDBP-64052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF144B
Protein Name ring finger protein 144B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000259939
InnateDB Gene IDBG-64050 (RNF144B)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. {ECO:0000269PubMed:12853982, ECO:0000269PubMed:20300062}.
Subcellular Localization Mitochondrion membrane {ECO:0000269PubMed:20300062}; Single-pass membrane protein {ECO:0000269PubMed:20300062}. Cytoplasm {ECO:0000269PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Disease Associations
Tissue Specificity Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. {ECO:0000269PubMed:16427630, ECO:0000269PubMed:20300062}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006915 apoptotic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR002867 Zinc finger, C6HC-type
PFAM PF13639
PF14634
PF01485
PRINTS
PIRSF
SMART SM00184
SM00647
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z419
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 255488
UniGene Hs.609528
RefSeq NP_877434
HUGO HGNC:21578
OMIM
CCDS CCDS34345
HPRD 17126
IMGT
EMBL AB076367 AK096832 AL138725 AL832329 BC063311 CH471087
GenPept AAH63311 BAC02434 BAG53370 CAD38622 CAI15148 EAW55407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca